The 2026 Complex Coronary Cases Symposium aims to provide a comprehensive, multi-device and evidence-based approach to revascularization in patients with complex coronary artery disease. The program will focus on complex left main disease, calcified bifurcation lesions, un-dilatable and diffuse calcified lesions, protected PCI and LV support, drug-coated balloon therapies, and the expanding role of artificial intelligence (AI) in interventional cardiology.

The meeting will highlight the “Top Ten Advances in Interventional Cardiology” and the “Top Five Breakthroughs in Cardiovascular Medicine in the Last Five Years”. A major emphasis will be placed on the integration of artificial intelligence into clinical decision-making, intravascular imaging, and procedural planning.

Live case presentations will showcase advanced techniques in complex left main interventions, calcium modification strategies including rotational and orbital atherectomy and intravascular lithotripsy, protected PCI, and the management of diffuse calcified bifurcation lesions in patients with reduced left ventricular function.

Focused controversy sessions will examine optimal device selection for calcium modification and the evolving role of drug-coated balloons in contemporary practice. The symposium will conclude with complex case discussions highlighting practical tips, troubleshooting strategies, and expert procedural insights.